منابع مشابه
Results Psd-95 Shrna
To address the unsolved question of PSD-95 function I used short hairpin RNA (shRNA) to knock-down protein expression. shRNA mediated knock-down of protein expression is one of the established methods exploiting the naturally occurring expression control mechanism known as RNA interference (RNAi). Cells express shRNAs that are complementary to the mRNA they control. The shRNAs are processed and...
متن کاملCellular/Molecular PSD-95 Uncouples Dopamine–Glutamate Interaction in the D1/PSD-95/NMDA Receptor Complex
Jingping Zhang,1 Tai-Xiang Xu,1 Penelope J. Hallett,2 Masahiko Watanabe,3 Seth G. N. Grant,4 Ole Isacson,2 and Wei-Dong Yao1 1New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, 2McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, 3Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060-8638, Japan, and 4Wellcome ...
متن کاملPSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex.
Classical dopaminergic signaling paradigms and emerging studies on direct physical interactions between the D(1) dopamine (DA) receptor and the NMDA glutamate receptor predict a reciprocally facilitating, positive feedback loop. This loop, if not controlled, may cause concomitant overactivation of both D(1) and NMDA receptors, triggering neurotoxicity. Endogenous protective mechanisms must exis...
متن کاملDelineation of additional PSD-95 binding domains within NMDA receptor NR2 subunits reveals differences between NR2A/PSD-95 and NR2B/PSD-95 association.
N-methyl-D-aspartate (NMDA) receptors are clustered at synapses via their association with the PSD-95 (post-synaptic density-95) membrane associated guanylate kinase (MAGUK) family of scaffolding proteins. PSD-95 is the best characterized of this family. It is known to associate with NMDA receptor NR2 subunits via a conserved ES(E/D)V amino acid sequence located at their C-termini and thus to p...
متن کاملIdentification of PSD-95 Palmitoylating Enzymes
UNLABELLED Postsynaptic density (PSD)-95, the most abundant postsynaptic scaffolding protein, plays a pivotal role in synapse development and function. Continuous palmitoylation cycles on PSD-95 are essential for its synaptic clustering and regulation of AMPA receptor function. However, molecular mechanisms for palmitate cycling on PSD-95 remain incompletely understood, as PSD-95 depalmitoylati...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2014
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2014.161